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Abirapro

Anticancer-Cancer-Treatment-Glenmark-Abiraterone-Acetate-250mg-Abirapro

Availability: In stock

Special Price $ 525

Abirapro DESCRIPTION

Abirapro (Abiraterone Acetate) Brand name: Abirapro Active Ingeridents(Generic Name) : Abiraterone Acetate Company Name: Zydus Package: 120 Tablets/bottle Strength: 250mg Indication: Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor. Abirapro (Abiraterone Acetate )is an androgen biosynthesis inhibitor. It works by decreasing... Read Below

Abirapro (Abiraterone Acetate)
Brand name: Abirapro
Active Ingeridents(Generic Name) : Abiraterone Acetate
Company Name: Zydus
Package: 120 Tablets/bottle
Strength: 250mg

Indication:
Treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.
Abirapro (Abiraterone Acetate )is an androgen biosynthesis inhibitor. It works by decreasing levels of certain hormones produced by the testes. This helps to prevent the growth of certain tumors that need these hormones to grow.
Mechanism of action:
Abiraterone, the active metabolite of abiraterone acetate, inhibits CYP17A1, which manifests as two enzymes, 17α-hydroxylase (IC50 = 2.5 nM) and 17,20-lyase (IC50 = 15 nM) (six-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase) that are expressed in testicular, adrenal, and prostatic tumor tissues. CYP17 catalyzes two sequential reactions: (a) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by its 17α-hydroxylase activity, and (b) the subsequent formation ofdehydroepiandrosterone (DHEA) and androstenedione, respectively, by its 17,20-lyase activity. DHEA and androstenedione are androgens and precursors of testosterone. Inhibition of CYP17 activity by abiraterone thus decreases circulating levels of androgens such as DHEA, testosterone, and dihydrotestosterone (DHT).
Abiraterone also acts as a partial antagonist of androgen receptors, and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase, CYP11B1 (steroid 11β-hydroxylase), and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).
Abirapro (Abiraterone Acetate )reduces serum testosterone levels to less than 1 ng/dL (i.e., undetectable), and decreases the weights of the prostate gland, seminal vesicles, and testes, in accordance with its antiandrogen action.


Dosage and Administration:
• Abirapro (Abiraterone Acetate )is a tablet, taken by mouth. It is taken once a day.
• It must be taken on an empty stomach [2 hours after a meal, or one hour before]
• It should be taken at approximately the same time each day.
• Prednisone [10mg daily] should be taken along with abiraterone acetate.
• The amount of Abirapro (Abiraterone Acetate )you receive depends on many factors. Your doctor will determine your dose and schedule

Side Effects:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Cough; diarrhea; heartburn; hot flushes; joint swelling or pain; mild muscle discomfort; tiredness; vomiting; weakness.

Precaution:

• Before starting Abirapro (Abiraterone Acetate )treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.
• Abirapro (Abiraterone Acetate )is currently not indicated for use in women. However, if Abirapro (Abiraterone Acetate )is given to a woman, getting pregnant should be avoided and the woman should not breast feed.

Store: Store Abirapro (Abiraterone Acetate ) at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Abirapro (Abiraterone Acetate )out of the reach of children and away from pets.