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BRAND : ViroClear
STRENGTH : 400mg
INGREDIENT : HepatitisC-Abbott-Sofosbuvir-400mg-Viroclear
COUNT : 28 Tablets

Description of ViroClear

Product Specification: Trade Name – Sovaldi * Brand Name – Viroclear * Composition – Sofosbuvir * Manufactured by – Abbott India.Ltd * Dose – Sofosbuvir 400 mg * Dosage Form – Tablets * Pack of 28 tablets in a bottle Viroclear is a generic version of sovaldi and manufactured by Abbott India.Ltd. Viroclear is type of classification of antiviral medication, it contain Sofosbuvir as active ingredient. Viroclear is prescription depended drug should be dispensed under the advice of the consultant.

Pharmacology of ViroClear

Pharmacodynamic:- Mechanism of action: Viroclear is a nucleotide polymerase inhibitor and includes in direct acting antiviral drug. Viroclear expose to have a high barrier to the development of resistance and inhibits the hep C NS5B protein. Thereby Viroclear prevents the enzyme RNA polymerase by the cellular worker who can performs the multiplication process, Hence Viroclear stops the replication of Hepatitis C virus and decrease the amount of Hep C virus in liver. Viroclear also acts to reduce damage in liver and improves function in liver. Pharmacokinetic:- • Absorption:- Administration of Viroclear was absorbed with peak plasma concentration of obtained at -0.5 to 2 hr post dose and in metabolite GS-331007 peak plasma concentration obtained between 2 to 4 hrs post dose. Effect of food: Viroclear and the metabolite have no affect with high fat meal. Hence Viroclear is administrated without food is effective. • Distribution: Viroclear is approx 51-65% bound to human plasma proteins and GS-331007 metabolite has minimal human plasma protein binding. • Metabolism: In liver, Viroclear is broadly metabolized (4% and >90%) to convert into pharmacologically active nucleoside analog triphosphate GS-461203. • Elimination: Mean total recovery of the Viroclear dose was >92%, involves of approx 80%,14% and 2.5% eliminated in urine, feces, expired air. • Half life of Viroclear and GS-331007 were 0.4 and 27hrs.

Indication of ViroClear

Viroclear is used to for the treatment of severe Hepatitis C virus in the liver, Hepatitis C virus is a long lasting infection of liver, Viroclear is highly effective medicine for this infection. Therefore Viroclear will decrease the action of hepatitis C Virus in our body and recover the liver from infection caused by virus.

Dose & Dosage's of ViroClear

• One tablet of Viroclear 400mg • Viroclear take Once in daily • With or without food • Duration of 12-24 weeks • Viroclear is administer through mouth(oral cavity)

Side Effects of ViroClear

Viroclear has common and serious effects. * Nausea and vomiting * Chills and fever * Pharyngtitis * Skin in pale colour * Lumbar pain * Myalgia * Weakness * Sleeping trouble * Diarrhea

Contraindication of ViroClear

Viroclear has no specific contraindications when used alone. When Viroclear in combination with ribavirin or peg interferon Alfa/ribavirin, or others, the contraindications also applicable to these agents are applied.

Drug Interaction of ViroClear

Viroclear in combination with simeprevir, daclatasvir and ledipasvir with amiodarone should not be used due to risk of irregular heartbeats. Viroclear with rifampicin (inducers of intestinal p- glycoprotein) will decrease the absorption of Sofosbuvir. Co-administration of Viroclear with anticonvulsants and the HIV protease inhibitors( Tipranavir, ritonavir) leads to decrease Viroclear concentration.

Precaution of ViroClear

* Patients undergoing treatment for Hepatitis C with Viroclear will require routine check up to their physician and blood check up to be followed.. * Risk of birth defect or harm to unborn baby, so pregnancy time, Viroclear should avoided. * Allergic to Sofosbuvir alone, then inform your consultant. * Viroclear Co-administration with amiodarone may occur serious bradycardia.

Usage & Safety profile of ViroClear Pregnancy & Lactation

Viroclear alone assigned a pregnancy category B, In all trimester there are no adequate and well tolerated studies in pregnant women, Since animal reproduction trial has no risks and adverse effect to the fetus. But Viroclear combination with ribavirin, assigned a pregnancy category X leads to birth defect and death to the fetus. Avoid combination therapy during pregnancy. While breast feeding the drugs pass into breast milk is unknown, therefore its recommended that mother should not breast feed during Viroclear alone and combination treatment.

Storage of ViroClear

• Viroclear 400 mg tablet should store below 300C (860F) • Viroclear Should be placed in cool and dry place • Viroclear should be packed in original container with sealed cap • Improper storage of Viroclear will affect effectiveness and shelf life • Viroclear should not kept in the glove compartment of a car. Regimen can get too hot, cold, or wet.