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Sovihep V

HepatitisC-Zydus-velpatasvir-100mg-Sofosbuvir-400mg-Sovihep-V

Availability: In stock

Special Price $ 650

BRAND : Sovihep V
STRENGTH : 400mg + 100mg
INGREDIENT : HepatitisC-Zydus-velpatasvir-100mg-Sofosbuvir-400mg-Sovihep-V
COMPANY NAME : Zydus
COUNT : 28 Tablets



Description of Sovihep V

Sovihep V Description:
Sovihep V is a combination medicine, contains an active ingredients like Sofosbuvir and Velpatasvir, both having anti-viral properties.
Sovihep V is active against virus which is responsible for chronic hepatitis C viral infection.
Sovihep V is a prescription medicine; it is used by the patient under the supervision of medical practitioner.
Sofosbuvir: HCV NS5B polymerase inhibitor
Velpatasvir: HCV NS5A inhibitor
Product details:
Trade name: Sovihep V
Active ingredients: Sofosbuvir and Velpatasvir
Strength of the drug: 400mg and 100mg respectively
Mfg: Zydus Cadila
Package: 28 tablets in a container
Category: Anti-viral

Pharmacology of Sovihep V

Pharmacology:
Sovihep V Mechanism of action:
Sovihep V containing two ingredients which exhibits antiviral activity,
Sofosbuvir: a nonstructural protein 5B polymerase inhibitor, essential for viral multiplication.
Sofosbuvir is a prodrug (nucleotide analog), metabolized into active form called uridine analogue triphosphate (GS-461203)
The metabolite GS-461203 is integrated into hepatitis C virus RNA by NS5B polymerase and performed as a chain terminator.
Velpatasvir: NS5A protein is responsible for RNA replication and aggregation of HCV virions.
Velpatasvir is a NS5A inhibitor which interfere with the enzyme activity and eradicates the viral multiply
Sovihep V Pharmacokinetics:
Absorption:
After oral administration of Sovihep V tablet, absorption occurs very quickly.
The peak plasma concentration of the Sofosbuvir, Velpatasvir and GS-461203 (active metabolite) occurs within 1 hour, 3 hours and 3 hours respectively.
Effect of food:
The response rate of both Sofosbuvir and Velpatasvir are similar to each other while taking with or without food.
Distribution:
Sofosbuvir is bound to human plasma protein in the range of 61-65%
Velpatasvir is highly bound to plasma protein around >99.5%
The active metabolite GS-461203 has poor protein binding property
Metabolism:
Sofosbuvir is largely metabolized in liver, converted to active analogue triphosphate GS-461203
Velpatasvir is eliminated greatly in unchanged form
Excretion:
80%, 14%, and 2.5% of the drug is eliminated through urine, faeces and exhaled air respectively.
The terminal half life of Tablet Sovihep V is 15 hours.

Indication of Sovihep V

Sovihep V Indication:
Sovihep V is primarily indicated for the patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection
There are two conditions like;
Without cirrhosis or with compensated cirrhosis
With decompensated cirrhosis with use of ribavirin

Dose & Dosage's of Sovihep V

Sovihep V Dosage and administration:
Sovihep V is mainly recommended for adults, safety and efficacy of the drug has not been established for children.
Chronic hepatitis C virus (HCV) infection genotypes I, II, III, IV, V or VI
One tablet to be taken as a single dose
Sovihep V should be taken with or without food
If patient without cirrhosis or compensated cirrhosis (child Pugh A) should take Sovihep V for 12 weeks
If patient with decompensated cirrhosis (child Pugh B or C) should take Sovihep V with ribavirin for 12 weeks
The dose of ribavirin recommended on the basis of weight of patient;
<75 kg: 1000mg/day twice daily
≥75 kg: 1200mg/day twice daily
The dosage of ribavirin should be decreased on the basis of hemoglobin and creatine clearance levels.
Missed dose:
If patient missed the dose of Sovihep V tablet, should be skipped and follow the next dose schedule
Do not take double dose

Side Effects of Sovihep V

Sovihep V Side effects:
Without cirrhosis
Headache, fatigue, shortness of breath, chest pain
With decompensated cirrhosis
Fatigue, anemia, decreased hemoglobulin levels, nausea, headache, insomnia
1-10% of patients attain;
Without cirrhosis;
Lipase increase, rash, depression, increased creatine kinase, insomnia, asthenia
With decompensated cirrhosis;
Diarrhea, hemoglobin levels get depleted, rash, increased creatine kinase

Contraindication of Sovihep V

Sovihep V Contraindication:
Sovihep V is contraindicated to the pregnant women or become pregnant and children
While taking Sovihep V with ribavirin causes some defects to the unborn babies

Drug Interaction of Sovihep V

Sovihep V Indication: Sovihep V is primarily indicated for the patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection There are two conditions like; Without cirrhosis or with compensated cirrhosis With decompensated cirrhosis with use of ribavirin

Precaution of Sovihep V

Sovihep V Precautions:
Care should be taking while using Sovihep V with ribavirin, amiodarone causes;
Serious effects to unborn baby
Bradycardia respectively
Patient with liver and kidney disorders

Usage & Safety profile of Sovihep V Pregnancy & Lactation

Pregnancy and lactation: Generally, Sovihep V is not prescribed for pregnant women and who become pregnant and children Sovihep V with ribavirin is contraindicated to pregnant women it may cause fetal death In lactation, some metabolites are excreted in human milk it also cause some ill effects

Storage of Sovihep V

Storage:
Sovihep V should be stored at room temperature.
Sovihep V container should be keep away from moisture, heat, and light