Description of Abamune-L
Trade name: Abamune L
Active ingredients: Abacavir and Lamivudine
Strength of the ingredients: Abacavir 600mg and Lamivudine 300mg
Container: 30 tablets
Abamune L description:
Abamune L is a combination tablet that contains ingredients like Abacavir and Lamivudine
Abamune L is involved in the treatment of HIV-type I infection, it is used with other anti-retroviral medicines to control the infections.
Abamune L is manufactured by cipla and it is active against HIV viruses which effectively prevent it from progressing to AIDS.
Pharmacology of Abamune-L
Mechanism of action:
Abacavir is a nucleoside reverse transcriptase inhibitor (carboxylic synthetic nucleoside analogue), it has activity against human immunodeficiency virus type I.
Abacavir is phosphorylated into an active metabolite carbovir triphosphate (deoxyguanosine 5’triphosphate) dGTP
This active metabolite prohibits the action of reverse transcriptase by competing with dGTP and inserted into viral DNA
The growth of viral DNA gets affected by insertion of nucleotide which causes lack of OH molecule.
OH molecules are essential for the formation of 5’ to 3’ phosphodiester linkage which is responsible for chain elongation.
Lamivudine is one of the ingredients present in Abamune L, it is nucleoside synthetic analogue.
Lamivudine is phosphorylated intracellularly into active 5’ triphosphate metabolite (lamivudine triphosphate 3TC-TP.
This active metabolite involves in inhibition of reverse transcriptase through chain termination after insertion of nucleotide analogue.
After oral administration of tablet Abamune L, abacavir and lamivudine is highly absorbed and its bioavailability occurs at 83% and 87% respectively
Abamune L is highly bound to human plasma protein nearly 50%; lamivudine has low plasma protein binding.
Abacavir metabolism occurred by alcohol dehydrogenase and glucuronyl transferase. Lamivudine is metabolized to trans-sulfoxide and biotransformation is catalyzed by sulfotransferases.
The terminal half life of abacavir and lamivudine is 1.54±0.63 hours and 5 to 7 hours respectively. Lamivudine is excreted in human milk
Indication of Abamune-L
Abamune L tablet is indicated for the treatment of HIV type I infection patients.
Dose & Dosage's of Abamune-L
The recommended dose of Abamune L tablet is one tablet to be taken orally as a single dose, in combination with other anti-retroviral medicines with or without food.
If patient not taken Tablet Abamune L, then the dose should be administered within the time
The particular dose should be skipped and continue the next drug schedule
Side Effects of Abamune-L
Fatal hypersensitivity reactions
Lactic acidosis and severe hepatomegaly with steatosis
Exacerbations of hepatitis B
Hepatic decompensated in patients co-infected with HIV-I and hepatitis C
Immune reconstitution syndrome
Some common side effects;
Insomnia, depression, headache, fatigue, dizziness, rash, pyrexia, abdominal pain, abnormal pain, anxiety
Contraindication of Abamune-L
Abamune L tablets are contraindicated in the patients having
HLA-B 5701 allele
Hypersensitivity reaction to components present in the product
Severe hepatic impairment
Drug Interaction of Abamune-L
If taking getting methadone maintenance therapy, with abacavir 600mg twice daily leads to increase the methadone clearance
HLA-B*5701 allele not co administered with abacavir due to anaphylactic reactions occurs
Ethanol blocks the ability of the kidney to eliminate the drug abacavir
Zalcitabine, it is not concomitant with Abamune L because the effect of lamivudine which is present in the drug and Zalcitabine are inhibits each other.
Precaution of Abamune-L
Caution with if patients having;
Hypersensitivity reactions, lactic acidosis, severe hepatomegaly with steatosis and exacerbations of hepatitis B
Fat redistribution, myocardial infarction, hepatic impairment
Usage & Safety profile of Abamune-L Pregnancy & Lactation
Abamune L causes birth defects to unborn babies
The use of Abamune L in pregnant women may have warrant in use
Breastfeeding mothers should not take Abamune L, it excreted in human milk
Nursing mothers not give milk to the babies; it might have chance of postnatal transmission.
Storage of Abamune-L
The storage condition of Abamune L tablets are at room temperature and keep it in dry place
It should be keep away from moisture, heat, and light