Description of Atavir
Trade name: Atavir
Category: Anti-retroviral agent
Atavir contains a prime ingredient known as Atazanavir, it is an anti-retroviral agent.
Anti-retroviral property of the drug Atazanavir exhibiting by prohibits the protease enzyme activity.
Atavir is a cipla product; it works by reducing the amount of HIV virus in blood by interfering with maturation of cells.
Atavir is not taken alone; it may combine with other anti-retroviral medicines like Ritonavir.
Pharmacology of Atavir
Mechanism of action:
Atavir is a protease inhibitor, this enzyme involved in cleavage of viral polyprotein
Atavir is effective against HIV type I infection, it inhibits the cleavage of Gag-Pol polyprotein.
This inhibition occurs by Atazanavir active form of Atavir, bounds to protease enzyme and stops the action produced by that particular enzyme
So the inhibition of cleavage leads to formation of immature cells.
The peak plasma concentration of the drug Atazanavir is occurred within 2.5 hours
Atavir (atazanavir) is highly bound to human plasma protein at nearly 86%
If Atavir taken with food, it may increase the bioavailability and reduce pharmacokinetic variability
Atavir is largely metabolized in liver.
The two major biotransformation pathways in Atavir is;
The elimination occurs through feces and urine.
The terminal half life of the drug in infected patients is approximately 6 hours.
Atavir Dosage and administration:
Atavir is combined with other anti-retroviral medicine like, Ritonavir
The recommended dose is 300mg should be taken orally as a single dose with 100mg ritonavir
If patient are not able to tolerate Ritonavir, 400mg of Atavir should be taken once a day with food
Atavir combined with efavirenz: 400mg PO with 100mg ritonavir qDay
Recommended dose: 300mg orally as a single dose
Combination with H2 receptor antagonist and tenofovir: 400mg PO with 100mg ritonavir qDay
Mild: 400mg PO qDay
Moderate: 300mg PO qDay
Severe: not recommended
Final stage of renal disease hemodialysis: 300mg PO with 100mg ritonavir qDay
6-18 years (treatment naïve and treatment experienced)
<15kg: Atavir is not recommended
15kg to <35kg: 200mg PO with 100mg ritonavir qDay
≥35kg: 300mg PO with 100mg ritonavir qDay
≥13 years (patient non tolerated to ritonavir)
≥40kg: 400mg PO qDay
Indication of Atavir
Atavir (Atazanavir), an anti retroviral medication used to treat HIV type I infection.
Atavir helps to reduce the amount of HIV virus in blood.
It reduce the chance of getting AIDS
Dose & Dosage's of Atavir
Atavir tablet is a prescription medicine; if patient fail to administer the dose, advice them to take within a time. Otherwise the missed dose should be skipped and follow the regular drug schedule
Side Effects of Atavir
Total bilirubin level elevated
Neutrophils counts depleted
Prolonged PR interval
QTc prolongation, pancreatitis, hepatic function abnormalities, cholelithiasis, arthralgia, alopecia
Contraindication of Atavir
Patients are contraindicated to the ingredients present in the Atavir tablet
Anaphylactic reaction occurs
Atavir is contraindicated in the conditions;
Chronic hepatitis B, C
High amount of bilirubin
Drug Interaction of Atavir
Some list of medicines get interacts with Atavir;
Alfuzosin, astemizole, carbamazepine, Cisapride, Cobimetinib, dihydroergotamine, ivabradine, simvastatin, lovastatin, pimozide, Phenobarbital, phenytoin, rifampin, sildenafil etc
Precaution of Atavir
Atavir should not used with proton pump inhibitor in treatment experienced patients
Tablet Atavir should be discontinue if patient getting severe rash or other anaphylactic reactions
Caution should be taken in case of
High bilirubin levels
Usage & Safety profile of Atavir Pregnancy & Lactation
Pregnancy category: B
Treatment experienced pregnant women during II or III trimester: co administration of Atavir with H2 receptor antagonist or tenofovir, a dose of 400mg with 100mg ritonavir as a single use
Maternal adverse effects:
Lactic acidosis, symptomatic hyperlactatemia, Hyperbilirubinaemia
Fetal/Neonatal adverse effects:
Not breastfeed to infants to prevent transmission of HIV-1 infection
Storage of Atavir
Atavir should be stored at room temperature, 68°F to 77°F (20°C to 25°C).
Container should be keep away from moisture, heat and light