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BRAND : Evertor
INGREDIENT : Anticancer-Cancer-Treatment-Biocon-Everolimus-10mg-Evertor
COUNT : 10 Tablets

Description of Evertor

Brand Name: Evertor Composition: Everolimus Manufactured by: Biocon Pharma Ltd. Strength: 10 mg Dosage Form: Tablets Packing: Pack of 10 Tablets ABOUT EVERTOR Evertor is brand name for the generic name of Everolimus. It is an antineoplastic drug. Everolimus is classified as “mTOR kinase inhibitor”and belongs to the class of immunosuppressants.

Pharmacology of Evertor

PHARMCODYNAMIC MECHANISM OF ACTION: Evertor is an inhibitor of mTOR. It prevents and stops the translation of genes which includes cancer cells reproduction. Evertor lowers the levels of certain cell growth factor that involved in the new blood vessels i.e vascular endothelial growth factor(VEGF) PHARMACOKINETICS ABSORPTIONS: Rapid absorption from the GI tract. Evertor can used with or without food. After oral administration of dose ranging from 5mg to 70mg the peak plasma concentration is 1-2hrs. DISTRIBUTION: Evertor given 10mg/day, the bounding of plasma protein is approx 74% both in healthy patients and patient with moderate liver impairment. METABOLISM: Evertor is a substrate of CYP3A4 and Pgp. It has six metabolites detected in human blood.three monohydroxylated metabolite, two hydrolytic ring opened products, and a phosphatidylcholine. Evertor inhibits metabolism of CYP3A4. ELIMINATION: Evertor excreted via feces 80% and urine 5% and the elimination half life is 30hrs.

Indication of Evertor

Evertor is indicated for combination treatment with exemestane for advanced breast cancer in postmenopausal women which failure of anastrozole and letrozole therapy. Evertor is also used for the treatment of certain advanced neuroendocrine tumors of pancreatic, gastrointestinal or lung origin. After failure of treatment with sunitinib for renal cell carcinoma(RCC), Evertor treatment is used.

Dose & Dosage's of Evertor

Evertor recommended dose is 10mg/day, If patient had liver problems th dose reduce according to severity (2.5,5 or 7.5mg/day).Always administer the drug according to the doctor’s advice. Take Evertor once a day at same time every day constantly either with or without food. Evertor should not be chew or crush the tablets, swallow it with a glass of water.

Side Effects of Evertor

Do not take Evertor and seek medical help immediately If you observe any of the following signs of an allergic reaction. • Allergic reaction: difficulty breathing or swallowing; swelling of the face,lips,tongue or throat,severe itching of the skin • Signs of infections:increased temperature,chills • Signs of lung inflammation: pneumonitis • Signs of diabetes: Excessive thirst, high urine output,tiredness • Sign of kidney failure: severe decreased urine output • Haemorrhage • Shortness of breath (rare patients) • Hypercholesterolemia • Inflammation of esophagitis

Contraindication of Evertor

Evetor contraindicated to patients with hypersensitivity to the active substance or rapamycin derivatives or any excipients.

Drug Interaction of Evertor

Evertor may affect the way some other medicines work. Evertor taking with other medicines on same time then, the dose of Evertor or the other medicines should be changed by a doctor.- used to treat fungal infections( ketoconazole, itraconazole, voriconazole, or fluconazole and other antifungals )-clarithromycin, telithromycin or erythromycin, antibiotics used to treat bacterial infections( clarithromycin, telithromycin or erythromycin). -ritonavir, efavirenz or nevirapine, used to treat HIV infection/AIDS( ritonavir, efavirenz or nevirapine).(verapamil or diltiazem), used to treat heart conditions or high blood pressure. The following may reduce the effectiveness of Evertor by rifampicin which, used to treat tuberculosis (TB).

Precaution of Evertor

Consult your doctor piror to use of evertor tablet and other medications which involves in prescription, over-the-counter, vitamins, herbal remedies, etc.and avoid Aspirin, or products related to aspirin your consultants permits this specifically. Any kind of immunization or vaccination should avoided unless your doctor's approval while administrating everolimus. Inform your Consltants if you are pregnant or planning to pregnant before starting the treatment In women and partner men: avoid conceive a child (get pregnant) while taking evertor. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy. Due to severe adverse reactions in the new born baby, breast-feeding is not recommended

Usage & Safety profile of Evertor Pregnancy & Lactation

Category C: Evertor is not recommended during pregnancy because It harm an unborn baby. Consult the doctor whether your pregnant or planning to be pregnant, he will discuss whether is medicine is suitable during pregnancy.

Storage of Evertor

* Evertor should use before the medicine expiry date. * Store in the original container of its own * Keep away the medicine from sight and reach of the medicine. * Evertor should be disposed in proper way, don’t throw away via waste water or household waste.