Veenat 100 (Imatinib)
Brand name: Veenat
Active Ingeridents(Generic Name) : Imatinib
Company Name : Natco Pharma
Package: 120 capsules
Strength : 100mg
Its use is advised against in patients on strong CYP3A4 inhibitors such as clarithromycin, chloramphenicol, ketoconazole, ritonavir andnefazodone due to its reliance on CYP3A4 for metabolism. Likewise it is a CYP3A4, CYP2D6 and CYP2C9 inhibitor and hence concurrent treatment with substrates of any of these enzymes may increase plasma concentrations of said drugs.
Mechanism of action:
Veenat (Imatinib) is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. It occupies the TK active site, leading to a decrease in activity.There are a large number of TK enzymes in the body, including the insulin receptor. Veenat (Imatinib) is specific for the TK domain in abl(the Abelson proto-oncogene), c-kit and PDGF-R (platelet-derived growth factor receptor).In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr(breakpoint cluster region), termed bcr-abl. As this is now aconstitutively active tyrosine kinase, Veenat (Imatinib) is used to decrease bcr-ablactivity.The active sites of tyrosine kinases each have a binding site for ATP.
Dosage and Administration:
Take the medicine with a large glass of water and food. This will help to avoid irritating the lining of your oesophagus (food pipe) and stomach.
The most common side effects include feeling sick (nausea), diarrhea, headaches, leg aches/cramps, fluid retention, visual disturbances, itchy rash, lowered resistance to infection, bruising or bleeding, loss of appetite; weight gain, reduced number of blood cells (neutropenia, thrombocytopenia, anemia), and edema. Although rare, restoration of hair color has been reported as well. Severecongestive cardiac failure is an uncommon but recognized side effect of Veenat (Imatinib) and mice treated with large doses of Veenat (Imatinib) show toxic damage to their myocardium.
The only known contraindication to Veenat (Imatinib) is hypersensitivity to Veenat (Imatinib). Cautions include:
Risk of severe CHF or left ventricular dysfunction, especially in patients with comorbidities
Pregnancy, risk of embryo-fetal toxicity
Risk of fluid retention
Risk of growth stunting in children or adolescents
Store: Veenat (Imatinib) room temperature away from moisture and heat.
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