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Votrient 400


Availability: In stock

Special Price $ 425

BRAND : Votrient
STRENGTH : 400mg
INGREDIENT : Anticancer-Cancer-Treatment-GSK-Pazopanib-400mg-Votrient
COUNT : 30 Tablets

Description of Votrient 400

Brand Name : Votrient Composition : Pazopanib Manufactured by : GlaxoSmithKline (GSK) Pharmaceuticals Ltd. Strength : 400 mg Dosage Form : Tablets Packing : Pack of 30 Tablets. ABOUT VOTRIENT Votrient400MG is a anticancer drug which inhibits the growth and spread of cancer cells in the body. Votrient is film-coated tablets , and a type of protein kinase inhibitors.

Pharmacology of Votrient 400

PHARMACODYNAMIC MECHANISM OF ACTION: Votrient 400mg is an protein kinase inhibitor of multiple receptor tyrosine kinases (RTKs) that are elaborate in beginning of signal transduction pathways that start to reproduction of malignant cells and affect processes critical to cell survival and tumour progression. RTKs involved in the obstruction include receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor (i.e. c-Kit). PHARMACOKINETIC Absorption: Votrient 400mg inadequately absorbed from the GI tract. Greater absorption with food. Bioavailability of Votrient: 14-39%. Duration of peak plasma concentration: 2-4 hr. Distribution: Plasma protein binding: >99%. Metabolism: Votrient 400mg metabolized in the liver mainly by CYP3A4 enzyme and to a lesser extent by CYP1A2 and CYP2C8 enzymes. Excretion: Votrient 400mg mainly excreted through faeces (approx 82%, 67% as unchanged drug) and urine (<4%). Elimination half-life: Approx 31 hr.

Indication of Votrient 400

VOTRIENT 400MG is indicated as a single agent for the treatment of kidney cancer and its advanced stage It works by inhibiting the activity of proteins which are interferes with the growth and spread of cancer cells. VOTRIENT 400mg is also indicated as a single regimen for the treatment of Soft Tissue Sarcoma, (a type of cancer that occurs in the supportive tissue of the body). The cancer can develop in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs

Dose & Dosage's of Votrient 400

Votrient 400MG dosage for kidney carcinoma and soft tissue sarcoma will be initially 800mg .Patients on strong CYP3A4 inhibitors. Dose reduced to 400 mg once daily and Votrient should be taken on a empty stomach (1hr before or 2hr after meals. Swallow the medicine whole don’t chew/crush. Avoid grapefruit juice or grapefruit juice.

Side Effects of Votrient 400

Major side effects: Diarrhae; High blood pressure; low WBC; Elevated liver function test; Blood test abnormalities; increased in bilirubin levels. Common Side effects: Nausea; loss of appetite; fatigue; blood test abnormalities (low magnesium, low glucose); weakness, stomach ache.

Contraindication of Votrient 400

Severe hepatic (total bilirubin >3 times ULN) impairment and Lactation by Continue use with strong P-glycoprotein (P-gp) or breast cancer resistance protein (BCRP) inducers and inhibitors and strong CYP3A4 enzyme inducers.

Drug Interaction of Votrient 400

Votrient 400MG with strong CYP3A4 enzyme inhibitors (e.g. ketoconazole, itraconazole, voriconazole, clarithromycin, telithromycin, atazanavir, indinavir, ritonavir, sqauinavir, nefazodone, lapatinib)will Increase plasma concentration. Votrient increases incidence of ALT elevation with simvastatin. Votrient 200mg with PPI e.g. esomeprazole decreases bioavailability. Votrient with Concomitant use of strong of P-gp or BCRP inhibitors (e.g. lapatinib) and inducers may alter the exposure and distribution of pazopanib. Votrient 200mg with rifampin(strong CYP3A4 Enzyme inducers) will decreases the plasma concentration.

Precaution of Votrient 400

Inform the piror to the treatment of Votrient 400mg tab about: • Any other mediactions, which include in prescription, over the counters,vitamins,herbal remedies. • Do not take immunization or vaccination without doctors advice. • Inform your doctor about pregnancy and planning to pregnant. • Do not breast feed while treatment with Votrient

Usage & Safety profile of Votrient 400 Pregnancy & Lactation

Category D: Votrient400MG show positive in human fetal effects, but the benefits from use in pregnant women may be acceptable against the risk .

Storage of Votrient 400

* Votrient 400mg store at 20-250C. * Votrient 400MG should store in locked cupboard in which children reach it. * Votrient 400MG do not use after expiry date. * Votrient must keep in its container till time to take the dose