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BRAND : Xbira
STRENGTH : 250mg
INGREDIENT : Anticancer-Cancer-Treatment-Cipla-Abiraterone-Acetate-250mg-Xbira
COUNT : 120 Tablets

Description of Xbira

Generic of the medicine: Abiraterone acetate Trade name of the medicine: X bira 250mg Mfg: cipla Container: 120 tablets X bira Description: Xbira is a one of the leading brand of Abiraterone. It is manufactured by cipla pvt ltd. X bira is exists under anti neoplastic drugs; it is act by depleting the androgen production in the body. Androgen is a male hormone which regulates the tumors cell in prostate glands. Generally this tablet is used by combining with prednisolone, a steroid which reduces the exposure of side effects produced by Abiraterone.

Pharmacology of Xbira

Mechanism of action: Androgens are responsible for production of tumors in prostate. X bira is an anti androgen medication, which leads to eradicate the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involved in androgen synthesis. Reduce the serum testosterone level. Depletion of tumor cell occurred. Pharmacokinetics: Absorption of tablet Xbira: The median plasma concentration of tablet Xbira takes 12 hours. Distribution of Xbira tablets Tablet Xbira is highly bound to the plasma protein like albumin and alpha-1 acid glycoprotein. Metabolism of Xbira tablets The metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate. Excretion of Xbira The mean terminal half life of tablet Xbira is 12 ± 5 hours. It is mainly excreted in 88% faeces and 5% in urine.

Indication of Xbira

Xbira is used in the treatment of patients with metastatic castration resistant prostate cancer who are previously received docetaxel with prednisolone. Xbira should be given with prednisolone to reduce the adverse effects which are produced by Xbira.

Dose & Dosage's of Xbira

The dose of Abiraterone is usually endorsed as 4 tablets orally once daily with 5mg prednisolone twice daily in empty stomach. Missed dose: If patient missed the dose of Abiraterone, that missed dose will be skipped and follow the regular dosing schedule.

Side Effects of Xbira

• Fatigue, • Arthralgia, • Hypertension, • Nausea, edema, • Hypokalemia, • Diarrhea, vomiting, • Cough, headache, • Glucocorticoid deficiency, • Mineral corticoid deficiency • Hepatotoxicity Hypertension, hypokalemia, fluid retention occurred due to mineral corticoid excess. Adrenocortical insufficiency Musculo skeletal and Connective tissue disorders: Joint swelling, discomfort, muscle discomfort General Disorder: Oedema Cardiac disorders: Hot flush, hypertension, arrhythmias, chest pain, cardiac failure GIT disorders: Diarrhea, dyspepsia Infections and Infestation: UTI Pulmonary disorder: Cough Renal: Urinary frequency, nocturia Injuries: Fractures

Contraindication of Xbira

Generally Xbira causes harm to the unborn babies. Xbira is contraindicated to the pregnant women or women who are become pregnant. Hypersensitivity reaction to the patient getting Xbira

Drug Interaction of Xbira

Avoid combination of Abiraterone acetate with strong CYP3A4 inducers, because it leads to increase Xbira dosing frequency Concomitant of ketaconazole with Xbira (strong CYP3A4 inhibitor) cause decrease the pharmacokinetic property of Xbira

Precaution of Xbira

Xbira tablet should be discontinued if patient having any allergy, severe liver problem, or pregnant. Care should be taken in case of; Hypertension, hypokalemia, fluid retention due to mineralocorticoid excess, adrenocortical insufficiency

Usage & Safety profile of Xbira Pregnancy & Lactation

Xbira tablet comes under pregnancy category X (leads to fetal death).

Storage of Xbira

Xbira is stored between 15oC-30oC in a dry place