Veenat 400 (Imatinib)
Brand name: Veenat
Active Ingeridents(Generic Name) : Imatinib
Company Name : natco
Package: 10 Tabs in strip
Strength : 400mg
Its use is advised against in patients on strong CYP3A4 inhibitors such as clarithromycin, chloramphenicol, ketoconazole, ritonavir andnefazodone due to its reliance on CYP3A4 for metabolism. Likewise it is a CYP3A4, CYP2D6 and CYP2C9 inhibitor and hence concurrent treatment with substrates of any of these enzymes may increase plasma concentrations of said drugs.
Mechanism of action:
Veenat (Imatinib) is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. It occupies the TK active site, leading to a decrease in activity.There are a large number of TK enzymes in the body, including the insulin receptor. Veenat (Imatinib) is specific for the TK domain in abl(the Abelson proto-oncogene), c-kit and PDGF-R (platelet-derived growth factor receptor).In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr(breakpoint cluster region), termed bcr-abl. As this is now aconstitutively active tyrosine kinase, Veenat (Imatinib) is used to decrease bcr-abl activity.The active sites of tyrosine kinases each have a binding site for ATP. The enzymatic activity catalyzed by a tyrosine kinase is the transfer of the terminal phosphate from ATP to tyrosine residues on its substrates, a process known as protein tyrosinephosphorylation.
Dosage and Administration:
Take the medicine with a large glass of water and food. This will help to avoid irritating the lining of your oesophagus (food pipe) and stomach.
If you are unable to swallow the tablets:
Put the required tablet(s) in a glass of water or apple juice (approximately 50 ml for a 100 mg tablet and 200 ml for a 400 mg tablet).
Stir with a spoon to completely disintegrate the tablet(s).
Immediately drink the whole contents of the glass.
For the best effect, take the medicine at about the same time each day.
Taking them at the same time each day will help you to remember to take them.
The most common side effects include feeling sick (nausea), diarrhea, headaches, leg aches/cramps, fluid retention, visual disturbances, itchy rash, lowered resistance to infection, bruising or bleeding, loss of appetite; weight gain, reduced number of blood cells (neutropenia, thrombocytopenia, anemia), and edema. Although rare, restoration of hair color has been reported as well. Severecongestive cardiac failure is an uncommon but recognized side effect of Veenat (Imatinib) and mice treated with large doses of Veenat (Imatinib) show toxic damage to their myocardium.
The only known contraindication to Veenat (Imatinib) is hypersensitivity to Veenat (Imatinib). Cautions include:
Risk of severe CHF or left ventricular dysfunction, especially in patients with comorbidities
Pregnancy, risk of embryo-fetal toxicity
Risk of fluid retention
Risk of growth stunting in children or adolescents
Store: Veenat 400 mg tablet room temperature away from moisture and heat.