Description of Votrient 200
* Brand Name : Votrient
* Composition : Pazopanib
* Manufactured by : GlaxoSmithKline (GSK) Pharmaceuticals Ltd.
* Strength : 200 mg
* Dosage Form : Tablets
* Packing : Pack of 30 Tablets.
Votrient 200MG is a anticancer drug which inhibits the growth and spread of cancer cells in the body. Votrient is film-coated tablets , and a type of protein kinase inhibitors.
Pharmacology of Votrient 200
MECHANISM OF ACTION:
Votrient 200mg is an protein kinase inhibitor of multiple receptor tyrosine kinases (RTKs) that are elaborate in beginning of signal transduction pathways that start to reproduction of malignant cells and affect processes critical to cell survival and tumour progression. RTKs involved in the obstruction include receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor.
Absorption: Votrient 200mg inadequately absorbed from the GI tract. Greater absorption with food. Bioavailability of Votrient: 14-39%. Duration of peak plasma concentration: 2-4 hr.
Distribution: Plasma protein binding: >99%.
Metabolism: Votrient 200mg metabolized in the liver mainly by CYP3A4 enzyme and to a lesser extent by CYP1A2 and CYP2C8 enzymes.
Excretion: Votrient 200mg mainly excreted through faeces (approx 82%, 67% as unchanged drug) and urine (<4%). Elimination half-life: Approx 31 hr.
Indication of Votrient 200
VOTRIENT 200MG is indicated as a single agent for the treatment of kidney cancer and its advanced stage It works by inhibiting the activity of proteins which are interferes with the growth and spread of cancer cells.
VOTRIENT 200mg is also indicated as a single regimen for the treatment of Soft Tissue Sarcoma, (a type of cancer that occurs in the supportive tissue of the body). The cancer can develop in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs
Dose & Dosage's of Votrient 200
Votrient dosage for kidney carcinoma and soft tissue sarcoma will be initially 800mg , the dose adjustment in 200mg increments or decrements dose based on tolerance but max dose in adult is 800mg/day.
Moderate total bilirubin >1.5 to 3 times, Votrient dose of 200mg once daily. Votrient should be taken on a empty stomach (1hr before or 2hr after meals. Swallow the medicine whole don’t chew/crush. Avoid grapefruit juice or grapefruit juice.
Side Effects of Votrient 200
Votrient 200mg Major side effects: Diarrhae; High blood pressure; low WBC; Elevated liver function test; Blood test abnormalities; increased in bilirubin levels.
Common Side effects: Nausea; loss of appetite; fatigue; blood test abnormalities (low magnesium, low glucose); weakness, stomach ache.
Contraindication of Votrient 200
Severe hepatic (total bilirubin >3 times ULN) impairment and Lactation by Continue use with strong P-glycoprotein (P-gp) or breast cancer resistance protein (BCRP) inducers and inhibitors and strong CYP3A4 enzyme inducers.
Drug Interaction of Votrient 200
Votrient 200mg with strong CYP3A4 enzyme inhibitors (e.g. ketoconazole, itraconazole, voriconazole, clarithromycin, telithromycin, atazanavir, indinavir, ritonavir, sqauinavir, nefazodone, lapatinib)will Increase plasma concentration. Votrient increases incidence of ALT elevation with simvastatin. Votrient 200mg with PPI e.g. esomeprazole decreases bioavailability.
Votrient 200mg with Concomitant use of strong of P-gp or BCRP inhibitors (e.g. lapatinib) and inducers may alter the exposure and distribution of pazopanib. Votrient 200mg with rifampin(strong CYP3A4 Enzyme inducers) will decreases the plasma concentration.
Precaution of Votrient 200
Inform the piror to the treatment of Votrient 200mg tab about:
• Any other mediactions, which include in prescription, over the counters,vitamins,herbal remedies.
• Do not take immunization or vaccination without doctors advice.
• Inform your doctor about pregnancy and planning to pregnant.
• Do not breast feed while treatment with Votrient
Usage & Safety profile of Votrient 200 Pregnancy & Lactation
Category D: Votrient show positive in human fetal effects, but the benefits from use in pregnant women may be acceptable against the risk .
Storage of Votrient 200
* Votrient 200mg store at 20-250C.
* Votrient should store in locked cupboard in which children reach it.
* Votrient do not use after expiry date.
* Votrient must keep in its container till time to take the dose.