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Ritomune

HIV-AIDS-Cipla-Ritonavir-100mg-Ritomune

Availability: In stock

Special Price $ 50

BRAND : Ritomune
STRENGTH : 100mg
INGREDIENT : HIV-AIDS-Cipla-Ritonavir-100mg-Ritomune
COMPANY NAME : Cipla
COUNT : 60 Tablets



Description of Ritomune

PRODUCT SPECIFICATION
Brand Name : RITOMUNE
Active ingredient: Ritonavir
Manufactured by : Cipla Ltd.
Strength : 100mg
Dosage Form : Tablets
Packing : Pack of 60 Tablets
ABOUT RITOMUNE
Ritomune should used with valid doctor’s prescription. It used for treatment for the infection caused by HIV. Ritomune is not a curable for HIV or prevention against AIDS. The patient who had no treatment for HIV in past will undergo therapy by Ritomune drug. It will target HIV infection from multiplying and decrease the destruction of immune system and delay the occurring HIV or AIDS disease.

Pharmacology of Ritomune

PHARMACODYNAMIC:
MECHANISM OF ACTION
Ritomune is a Competitive, particular and reversible HIV protease inhibitor which includes with the essential formation of proteins and enzymes. Ritomune inhibits the virus infection and causes ineffective, premature and non-infectious virions development.
PHARMACOKINETIC
ABSORPTION: Fast absorption from the GI tract, absorption increased with food, peak plasma concentration is approx 2-4hr.
DISTRIBUTION: Minimal amount distribution enters into CNS, volume of distribution about 0.16-0.66 L/kg. binding of plasma protein is approx 98%.
METABOLISM: Ritomune is mainly metabolized in liver by CYP3A4 & lesser extent by CYP2D6 isoenzymes.
ELIMINATION: Ritomune exceted by both unchanged and metabolite via faeces approx 86% and 3.5% as unchanged drug via urine approx 11%. The terminal elimination half life is 3-5hr.

Indication of Ritomune

Ritomune is mainly used in adult by combination with antiretroviral drugs for the treatment of HIV infection.

Dose & Dosage's of Ritomune

Ritomune administration in adult, initially 300mg twice daily (bid) for 3 days. Gradually increased the dose to 100mg (bid) for 14days; Max dose of Ritomune drug is 600mg
In children, starting with 250mg/m2 twice daily, gradually increased by 50mg/m2 bid for 2-3 day intervals upto 350-400mg/m2bid. Max dose is 600mg bid.
Ritomune administrated through oral route with food, one tablet same time every day.

Side Effects of Ritomune

~ GI effects: abdominal pain, nausea, vomiting, diarrhea, anorexia
~ Common side effects: asthenia, taste disorder, headache, numbness or tingling around the mouth or extremities, anxiety, insomnia, fever, dizziness, malaise, hyperaesthesia, pharyngitis, rash, pruritus, sweating, vasodilatation, wt loss,
~ Allergic reactions : urticaria, bronchospasm, angioedema, mild skin eruptions, immune reconstitution syndrome, lipodystrophy, osteonecrosis,
~ Metabolic abnormalities: hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycaemia, hyperlactataemia.
~ Reduced levels of Hb, K, free and total thyroxine; increased eosinophil, liver enzymes, amylase and uric acid; reduced or increased WBC and neutrophil counts.
~ Major side effects: Pancreatitis, hepatic dysfunction, Stevens-Johnson syndrome. Rarely, anaphyla.

Contraindication of Ritomune

Drug Interaction of Ritomune

Ritomune is mainly used in adult by combination with antiretroviral drugs for the treatment of HIV infection.

Precaution of Ritomune

Before taking Ritomune, inform your doctors about as follows:
Patient with ischaemic heart disease, cardiomyopathy, pre-existing conduction abnormalities or structural heart disease, haemophilia A or B, porphyria, increased triglycerides.
Renal and severe hepatic impairment without decompensation in Childern& Pregnancy.
Monitoring Parameters Monitor cholesterol, triglycerides, CBC, LFTs, creatine phosphokinase, uric acid,viral load,CD4 count, serum amylase and lipase, glucose.

Usage & Safety profile of Ritomune Pregnancy & Lactation

Category B: Animal studies have been developed adverse effect, but sufficient and well-tolerated studies in pregnant women which have failed to develop arisk to the fetus in all trimester in pregnancy

Storage of Ritomune

* Ritomune store at 20-250C.
* Store at cool and dry place
* Keep Ritomune tablet away from the children.
* Use Ritomune drug before expiry date.