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Resof Total


Availability: In stock

Special Price $ 325

BRAND : Resof Total
STRENGTH : 400 mg & 100 mg
INGREDIENT : HepatitisC-DrReddys-Velpatasvir-100mg-Sofosbuvir-400mg-Resof-Total
COMPANY NAME : Dr. Reddy's
COUNT : 28 Tablets

Description of Resof Total

Resof total Description: Resof Total is a combination medicine, contains an active ingredients like Sofosbuvir and Velpatasvir, both having anti-viral properties. Resof Total is active against virus which is responsible for chronic hepatitis C viral infection. Resof Total is a prescription medicine; it is used by the patient under the supervision of medical practitioner. Sofosbuvir: HCV NS5B polymerase inhibitor Velpatasvir: HCV NS5A inhibitor Product details: Trade name: Resof Total Active ingredients: Sofosbuvir and Velpatasvir Strength of the drug: 400mg and 100mg respectively Mfg: Dr. Reddy’s Package: 28 tablets in a container Category: Anti-viral

Pharmacology of Resof Total

Pharmacology: Resof Total Mechanism of action: Resof Total containing two ingredients which exhibits antiviral activity, Sofosbuvir: a nonstructural protein 5B polymerase inhibitor, essential for viral multiplication. Sofosbuvir is a prodrug (nucleotide analog), metabolized into active form called uridine analogue triphosphate (GS-461203) The metabolite GS-461203 is integrated into hepatitis C virus RNA by NS5B polymerase and performed as a chain terminator. Velpatasvir: NS5A protein is responsible for RNA replication and aggregation of HCV virions. Velpatasvir is a NS5A inhibitor which interfere with the enzyme activity and eradicates the viral multiply Resof Total Pharmacokinetics: Absorption: After oral administration of Resof Total tablet, absorption occurs very quickly. The peak plasma concentration of the Sofosbuvir, Velpatasvir and GS-461203 (active metabolite) occurs within 1 hour, 3 hours and 3 hours respectively. Effect of food: The response rate of both Sofosbuvir and Velpatasvir are similar to each other while taking with or without food. Distribution: Sofosbuvir is bound to human plasma protein in the range of 61-65% Velpatasvir is highly bound to plasma protein around >99.5% The active metabolite GS-461203 has poor protein binding property Metabolism: Sofosbuvir is largely metabolized in liver, converted to active analogue triphosphate GS-461203 Velpatasvir is eliminated greatly in unchanged form Excretion: 80%, 14%, and 2.5% of the drug is eliminated through urine, faeces and exhaled air respectively. The terminal half life of Tablet Resof Total is 15 hours.

Indication of Resof Total

Resof Total Indication: Resof Total is primarily indicated for the patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection There are two conditions like; Without cirrhosis or with compensated cirrhosis With decompensated cirrhosis with use of ribavirin

Dose & Dosage's of Resof Total

Resof Total Dosage and administration: Resof Total is mainly recommended for adults, safety and efficacy of the drug has not been established for children. Chronic hepatitis C virus (HCV) infection genotypes I, II, III, IV, V or VI One tablet to be taken as a single dose Resof Total should be taken with or without food If patient without cirrhosis or compensated cirrhosis (child Pugh A) should take Resof Total for 12 weeks If patient suffered with decompensated cirrhosis (child Pugh B or C) should take Resof Total with ribavirin for 12 weeks The dose of ribavirin recommended on the basis of weight of patient; <75 kg: 1000mg/day twice daily ≥75 kg: 1200mg/day twice daily The dosage of ribavirin should be decreased on the basis of hemoglobin and creatine clearance levels. Missed dose: If patient missed the dose of Resof Total tablet, should be skipped and follow the next dose schedule Do not take double dose

Side Effects of Resof Total

Resof Total Side effects: Without cirrhosis Headache, fatigue, shortness of breath, chest pain With decompensated cirrhosis Fatigue, anemia, decreased hemoglobulin levels, nausea, headache, insomnia 1-10% of patients attain; Without cirrhosis; Lipase increase, rash, depression, increased creatine kinase, insomnia, asthenia With decompensated cirrhosis; Diarrhea, hemoglobin levels get depleted, rash, increased creatine kinase

Contraindication of Resof Total

Resof Total Contraindication: Resof Total is contraindicated to the pregnant women or become pregnant and children While taking Resof Total with ribavirin causes some defects to the unborn babies

Drug Interaction of Resof Total

Resof Total Drug interaction: The potentially significant drug interaction occurs while concomitant with some medicines; Acid reducing agents like Aluminium and magnesium hydroxide, H2 receptor antagonist like famotidine, proton pump inhibitors like Omeprazole these drugs are reduce the effect of concentration of Velpatasvir Antiarrhythmic drug like amiodarone when co administered with Resof Total leads to life threatening condition like symptomatic bradycardia While concomitant with digoxin, the effect of concentration of digoxin will get elevated Anticancer drug like topotecan, co administration is not recommended because of elevation of effect of concentration of topotecan Some list of medicines causes drug interactions like; Carbamazepine, phenytoin, Phenobarbital, oxcarbazepine, rifampin, rifabutin, rifapentine, efavirenz, St. John’s wort, rosuvastatin and Atorvastatin

Precaution of Resof Total

Resof Total Precautions: Care should be taking while using Resof Total with ribavirin, amiodarone causes; Serious effects to unborn baby Bradycardia respectively Patient with liver and kidney disorders

Usage & Safety profile of Resof Total Pregnancy & Lactation

Pregnancy and lactation: Generally, Resof Total is not prescribed for pregnant women and who become pregnant and children Resof Total with ribavirin is contraindicated to pregnant women it may cause fetal death In lactation, some metabolites are excreted in human milk it also cause some ill effects

Storage of Resof Total

Storage: Resof Total should be stored at room temperature. Resof Total container should be keep away from moisture, heat, and light