Support in USA : 1-978- 707-9553 / Support in India : +91- 9987711567

  • Apple Pharmaceuticals

Myhep All


Availability: In stock

Special Price $ 350

BRAND : Myhep All
STRENGTH : 400 mg & 100 mg
INGREDIENT : HepatitisC-Mylan-Velpatasvir-100mg-Sofosbuvir-400mg-Myhep-ALL
COUNT : 28 Tablets

Description of Myhep All

Myhep All is a combination medicine, contains an active ingredients like Sofosbuvir and Velpatasvir, both having anti-viral properties. Myhep All is active against virus which is responsible for chronic hepatitis C viral infection. Myhep All is a prescription medicine; it is used by the patient under the supervision of medical practitioner. Sofosbuvir: HCV NS5B polymerase inhibitor Velpatasvir: HCV NS5A inhibitor Product details: Trade name: Myhep All Active ingredients: Sofosbuvir and Velpatasvir Strength of the drug: 400mg and 100mg respectively Mfg: Mylan Package: 28 tablets in a container Category: Anti-viral

Pharmacology of Myhep All

Myhep All Mechanism of action: Myhep All containing two ingredients which exhibits antiviral activity, Sofosbuvir: a nonstructural protein 5B polymerase inhibitor, essential for viral multiplication. Sofosbuvir is a prodrug (nucleotide analog), metabolized into active form called uridine analogue triphosphate (GS-461203) The metabolite GS-461203 is integrated into hepatitis C virus RNA by NS5B polymerase and performed as a chain terminator. Velpatasvir: NS5A protein is responsible for RNA replication and aggregation of HCV virions. Velpatasvir is a NS5A inhibitor which interfere with the enzyme activity and eradicates the viral multiply Myhep All Pharmacokinetics: Absorption: After oral administration of Myhep All tablet, absorption occurs very quickly. The peak plasma concentration of the Sofosbuvir, Velpatasvir and GS-461203 (active metabolite) occurs within 1 hour, 3 hours and 3 hours respectively. Effect of food: The response rate of both Sofosbuvir and Velpatasvir are similar to each other while taking with or without food. Distribution: Sofosbuvir is bound to human plasma protein in the range of 61-65% Velpatasvir is highly bound to plasma protein around >99.5% The active metabolite GS-461203 has poor protein binding property Metabolism: Sofosbuvir is largely metabolized in liver, converted to active analogue triphosphate GS-461203 Velpatasvir is eliminated greatly in unchanged form Excretion: 80%, 14%, and 2.5% of the drug is eliminated through urine, faeces and exhaled air respectively. The terminal half life of Tablet Myhep All is 15 hours.

Indication of Myhep All

Myhep All Indication: Myhep All is primarily indicated for the patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection There are two conditions like; Without cirrhosis or with compensated cirrhosis With decompensated cirrhosis with use of ribavirin

Dose & Dosage's of Myhep All

Myhep All Dosage and administration: Myhep All is mainly recommended for adults, safety and efficacy of the drug has not been established for children. Chronic hepatitis C virus (HCV) infection genotypes I, II, III, IV, V or VI One tablet to be taken as a single dose Myhep All should be administered with or without food If patient without cirrhosis or compensated cirrhosis (child Pugh A) should take Myhep All for 12 weeks If patient with decompensated cirrhosis (child Pugh B or C) should take Myhep All with ribavirin for 12 weeks The dose of ribavirin recommended on the basis of weight of patient; <75 kg: 1000mg/day twice daily ≥75 kg: 1200mg/day twice daily The dosage of ribavirin should be decreased on the basis of hemoglobin and creatine clearance levels. Missed dose: If patient missed the dose of Myhep All tablet, should be skipped and follow the next dose schedule Do not take double dose

Side Effects of Myhep All

Myhep All Side effects: Without cirrhosis Headache, fatigue, shortness of breath, chest pain With decompensated cirrhosis Fatigue, anemia, decreased hemoglobulin levels, nausea, headache, insomnia 1-10% of patients attain; Without cirrhosis; Lipase increase, rash, depression, increased creatine kinase, insomnia, asthenia With decompensated cirrhosis; Diarrhea, hemoglobin levels get depleted, rash, increased creatine kinase

Contraindication of Myhep All

Myhep All Contraindication: Myhep All is contraindicated to the pregnant women or become pregnant and children While taking Myhep All with ribavirin causes some defects to the unborn babies

Drug Interaction of Myhep All

Myhep All Drug interaction: The potentially significant drug interaction occurs while concomitant with some medicines; Acid reducing agents like Aluminium and magnesium hydroxide, H2 receptor antagonist like famotidine, proton pump inhibitors like Omeprazole these drugs are reduce the effect of concentration of Velpatasvir Antiarrhythmic drug like amiodarone when co administered with Myhep All leads to life threatening condition like symptomatic bradycardia While concomitant with digoxin, the effect of concentration of digoxin will get elevated Anticancer drug like topotecan, co administration is not recommended because of elevation of effect of concentration of topotecan Some list of medicines causes drug interactions like; Carbamazepine, phenytoin, Phenobarbital, oxcarbazepine, rifampin, rifabutin, rifapentine, efavirenz, st. John’s wort, rosuvastatin and Atorvastatin.

Precaution of Myhep All

Myhep All Precautions: Care should be taking while using Myhep All with ribavirin, amiodarone causes; Serious effects to unborn baby Bradycardia respectively Patient with liver and kidney disorders

Usage & Safety profile of Myhep All Pregnancy & Lactation

Generally, Myhep All is not prescribed for pregnant women and who become pregnant and children Myhep All with ribavirin is contraindicated to pregnant women it may cause fetal death In lactation, some metabolites are excreted in human milk it also cause some ill effects

Storage of Myhep All

Myhep All should be stored at room temperature. Myhep All container should be keep away from moisture, heat, and light