Description of Resof Total - 12 weeks
Trade name: Resof Total
Active ingredients: Sofosbuvir and Velpatasvir
Strength of the drug: 400mg and 100mg respectively
Mfg: Dr. Reddy’s
Package: 28 tablets in a container
Category: Anti-viral drug
Resof total Description:
Resof Total is active against virus which is responsible for chronic hepatitis C viral infection.
Resof Total is a combination medicine, contains an active ingredients like Sofosbuvir and Velpatasvir, both having anti-viral properties.
Sofosbuvir: HCV NS5B polymerase inhibitor
Velpatasvir: HCV NS5A inhibitor
Resof Total is a prescription medicine; it is used by the patient under the supervision of medical practitioner.
Pharmacology of Resof Total - 12 weeks
Resof Total Mechanism of action:
Resof Total containing two ingredients which exhibits antiviral activity,
Sofosbuvir works by inhibiting viral replication
Sofosbuvir is metabolized into uridine analogue triphosphate (GS-461203) which is a active form
The metabolite GS-461203 is incorporated into hepatitis C virus RNA by NS5B polymerase and performed as a chain terminator.
Velpatasvir: NS5A protein is responsible for RNA replication and aggregation of HCV virions.
Velpatasvir is a NS5A inhibitor which interfere with the enzyme activity and eradicates the viral multiply
Resof Total Pharmacokinetics:
Resof Total tablet, absorption occurs very quickly.
The peak plasma concentration of the Sofosbuvir- 1 hour, Velpatasvir- 3 hours and GS-461203- 3 hours (active metabolite)
Human plasma protein of Sofosbuvir in the range of 61-65%
Velpatasvir around >99.5%
The active metabolite GS-461203 has poor protein binding property
Sofosbuvir is largely metabolized in liver, changed to active analogue triphosphate GS-461203
Velpatasvir is eliminated greatly in unchanged form
80%, 14%, and 2.5% of the drug is eliminated through urine, faeces and exhaled air respectively.
The terminal half life of Tablet Resof Total is 15 hours.
Indication of Resof Total - 12 weeks
Resof Total is primarily indicated for the patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection
There are two conditions like;
Without cirrhosis or with compensated cirrhosis
With decompensated cirrhosis with use of ribavirin
Dose & Dosage's of Resof Total - 12 weeks
Resof Total is mainly recommended for adults, safety and efficacy of the drug has not been established for children.
Chronic hepatitis C virus (HCV) infection genotypes I, II, III, IV, V or VI
One tablet to be taken as a single dose
Resof Total should be taken with or without food
In compensated cirrhosis: Resof Total tablet should be taken for 12 weeks
In decompensated cirrhosis: Resof Total with ribavirin should be taken for 12 weeks
The dose of ribavirin recommended on the basis of weight of patient;
<75 kg: 1000mg/day twice daily
≥75 kg: 1200mg/day twice daily
The dosage of ribavirin should be decreased on the basis of hemoglobin and creatine clearance levels.
If patient missed the dose of Resof Total tablet, should be skipped and follow the next dose schedule
Do not take double dose
Side Effects of Resof Total - 12 weeks
Headache, fatigue, shortness of breath, chest pain
With decompensated cirrhosis
Fatigue, anemia, decreased hemoglobulin levels, nausea, headache, insomnia
1-10% of patients attain;
Lipase increase, rash, depression, increased creatine kinase, insomnia, asthenia
With decompensated cirrhosis;
Diarrhea, hemoglobin levels get depleted, rash, increased creatine kinase
Contraindication of Resof Total - 12 weeks
Resof Total is contraindicated to the pregnant women or become pregnant and children
While taking Resof Total with ribavirin causes some defects to the unborn babies
Drug Interaction of Resof Total - 12 weeks
The potentially significant drug interaction occurs while concomitant with some medicines;
Acid reducing agents like Aluminium and magnesium hydroxide, H2 receptor antagonist like famotidine, proton pump inhibitors like Omeprazole these drugs are reduce the effect of concentration of Velpatasvir
Antiarrhythmic drug like amiodarone when co administered with Resof Total leads to life threatening condition like symptomatic bradycardia
While concomitant with digoxin, the effect of concentration of digoxin will get elevated
Anticancer drug like topotecan, co administration is not recommended because of elevation of effect of concentration of topotecan
Some list of medicines causes drug interactions like;
Carbamazepine, phenytoin, Phenobarbital, oxcarbazepine, rifampin, rifabutin, rifapentine, efavirenz, St. John’s wort, rosuvastatin and Atorvastatin
Precaution of Resof Total - 12 weeks
Care should be taking while using Resof Total with ribavirin, amiodarone causes;
Serious effects to unborn baby
Patient with liver and kidney disorders
Usage & Safety profile of Resof Total - 12 weeks Pregnancy & Lactation
Generally, Resof Total is not prescribed for pregnant women and who become pregnant and children
Resof Total with ribavirin is contraindicated to pregnant women it may cause fetal death
In lactation, some metabolites are excreted in human milk it also cause some ill effects
Storage of Resof Total - 12 weeks
Resof Total should be stored at room temperature.
Resof Total container should be keep away from moisture, heat, and light