Support in USA : 1-978- 707-9553 / Support in India : +91- 9987711567

  • Apple Pharmaceuticals

Velpaclear - 12 weeks

HepatitisC-Abbot-Velpatasvir-100mg-Sofosbuvir-400mg-Velpaclear

Availability: In stock

Special Price $ 825

BRAND : Velpaclear
STRENGTH : 400 mg & 100 mg
INGREDIENT : HepatitisC-Abbot-Velpatasvir-100mg-Sofosbuvir-400mg-Velpaclear
COMPANY NAME : Abbott
COUNT : 28 Tablets



Description of Velpaclear - 12 weeks

Brand name: Velpaclear Active component: Sofosbuvir and Velpatasvir Strength of the components: 400mg and 100mg respectively Mfg: Abbott Package: 28 tablets in a container Category: Anti-viral agent Description – 12 weeks Velpaclear is a prescription medicine; it is taken by the patients only under the guidance of medical practitioner Velpaclear is a fixed dose combination drug, contains Sofosbuvir and Velpatasvir as an active ingredients. Both the components exhibit anti-viral activity. Velpaclear tablet is active against virus which causes hepatitis C infection in adults Velpaclear has two components; Sofosbuvir-HCV NS5B polymerase inhibitor Velpatasvir-HCV NS5A inhibitor

Pharmacology of Velpaclear - 12 weeks

Velpaclear – Treatment for chronic hepatitis C viral infection for 12 weeks Velpatasvir HCV NS5A protein inhibitor, it blocks the protein activity and inhibits viral multiplication. Sofosbuvir is one of the component of Myhep All tablet, is an HCV NS5B RNA polymerase inhibitor This undergoes intracellular metabolism to form uridine analogue triphosphate Inhibition of viral multiplication occurs by incorporating into HCV RNA and acts as a chain terminator Pharmacokinetic: 12 weeks Absorption: The Velpaclear tablet was quickly absorbed after oral administration. The peak plasma concentration of both component in Velpaclear and active metabolite of Velpaclear (GS-461203) occurs within 1 hour, 3 hours, and 3 hours respectively Distribution: Food does not interfere with Velpaclear action Sofosbuvir, Plasma protein binding: 61-65% Velpatasvir, plasma protein bound: >99.5% The active metabolite of the tablet Velpaclear has poor protein binding property. Metabolism: Sofosbuvir is metabolized in liver, changed to active analogue triphosphate GS-461203 Elimination: 80% metabolite eliminated: urine; 14% of metabolites: faeces; 2.5%: exhaled air The terminal half life of Velpaclear tablet is 15 hours

Indication of Velpaclear - 12 weeks

Velpaclear is mainly indicated for the patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection. Generally Velpaclear tablets are taken for 12 weeks, it may effective in patients. Types of hepatitis Without cirrhosis or with compensated cirrhosis With decompensated cirrhosis with use of ribavirin

Dose & Dosage's of Velpaclear - 12 weeks

Velpaclear is recommended for adults. The safety and efficacy of the drug has not been established for children. Chronic hepatitis C virus (HCV) infection genotypes I, II, III, IV, V or VI One tablet to be taken as a single dose Velpaclear should be taken with or without food Without cirrhosis or with compensated cirrhosis: Velpaclear taken for 12 weeks In decompensated or advanced cirrhosis: Velpaclear with ribavirin for 12 weeks The dose of ribavirin recommended on the basis of weight of patient; <75 kg: 1000mg/day twice daily ≥75 kg: 1200mg/day twice daily The dosage of ribavirin should be decreased on the basis of hemoglobin and creatine clearance levels. Missed dose: If patient missed the dose of Velpaclear tablet, should be skipped and follow the next dose schedule Do not take double dose

Side Effects of Velpaclear - 12 weeks

* Chest pain * Lightheadness, dizziness or fainting * Breathing difficulty * Irregular heartbeats * Unusual tiredness * Fatigue, headache * Sleeping trouble * Loss of appetite * Angioedema

Contraindication of Velpaclear - 12 weeks

Velpaclear while combining with ribavirin for advanced cirrhosis, in this condition it is contraindicated to the pregnant women and women who become pregnant, ribavirin cause harm to the fetal

Drug Interaction of Velpaclear - 12 weeks

While taking Velpaclear for 12 weeks, some of the drugs should not take in combination; Ant acids: aluminium hydroxide, magnesium hydroxide, calcium carbonate H2 receptor antagonist: famotidine, ranitidine, Cimetidine Proton pump inhibitors: Omeprazole, esomeprozole, pantoprazole, lansoprazole Anti-arrhythmic: amiodarone, digoxin Anti-cancer: topotecan Anti-mycobacterials: rifabutin, rifampin, rifapentine HIV antiretroviral: efavirenz, tenofovir, tipranavir ritonavir Herbal supplements: st. Johns wort Anti convulsants: carbamazepine, phenytoin, Phenobarbital, oxcarbazepine HMG CoA reductase inhibitors: rosuvastatin, Atorvastatin

Precaution of Velpaclear - 12 weeks

Risk of HBV reactivation in patient co infected with HCV and HBV Co administration of amiodarone with Velpaclear causes bradycardia; caution should be taking while combining with amiodarone Caution with use in Liver and kidney impairment patients

Usage & Safety profile of Velpaclear - 12 weeks Pregnancy & Lactation

~ Velpaclear with ribavirin is not safe to use in pregnancy condition, it may leads to fetal death ~ Breast feeding is not recommended

Storage of Velpaclear - 12 weeks

~ Velpaclear should be stored at room temperature. ~ Velpaclear container should be keep away from moisture, heat, and light