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Hepcdac - 12 weeks

HepatitisC-Cipla-Daclatasvir-60mg-Hepcdac

Availability: In stock

Special Price $ 399

BRAND : Hepcdac
STRENGTH : 60mg
INGREDIENT : HepatitisC-Cipla-Daclatasvir-60mg-Hepcdac
COMPANY NAME : Cipla
COUNT : 28 Tablets



Description of Hepcdac - 12 weeks

Product Index: Trade name: Hepcdac Active component: Daclatasvir Strength: 60mg Mfg: Cipla Pack: 28 tablets in a container Category: Anti-viral Description of Hepcdac 12 weeks Hepatitis C virus is a RNA virus, which causes severe life threatening conditions like;  Chronic hepatitis  Cirrhosis  Hepatocellular carcinoma Hepcdac is an anti-viral medication, which is available in tablet form. Hepcdac exhibits its action by prohibiting the non structural 5A protein region of hepatitis C virus Hepcdac is not monotherapy medicine; it should be combined with other anti-viral drugs for treating chronic hepatitis C infection caused by virus Hepcdac is available in the strength of 60mg

Pharmacology of Hepcdac - 12 weeks

Hepcdac is a NS5A inhibitors, NS5A protein is required for viral multiplication This NS5A has capability to merge with HCV RNA. There are two specific functions in RNA multiplication which is based on phosphorylated state Cis acting function of phosphorylated NS5A: Interfering HCV replication complex; Trans acting function: regulate HCV assembly and infectious particle production Hepcdac will disrupt hyperphosphorylated NS5A protein and mediated with newly formed RNA viral Hepcdac involved in blockade of intercellular viral RNA synthesis and colony of virion Pharmacokinetic: Hepcdac 12 weeks Absorption: The peak plasma concentration of Hepcdac occurs within 2 hours. The mean bioavailability of Hepcdac is 67% The steady state level reached in 4 days after administration of single dose Distribution: The volume of distribution occurs at 47L. The human plasma protein bound with Hepcdac with the range of 99% Metabolism: Dalsiclear a CYP3A substrates, it is dominantly metabolized by CYP3A4 isoenzymes High portion of Hepcdac in plasma is in unchanged form nearly 97% Elimination: The route of elimination of metabolites; Bile: 88%; feces 53% (unchanged form) and 6.6% in unchanged form through urine The mean terminal half life period of Hepcdac occurs from the range of almost 12 to 15 hours

Indication of Hepcdac - 12 weeks

Dose & Dosage's of Hepcdac - 12 weeks

Before initiating the therapy; NS5A resistance testing in HCV genotype 1a infected patients with cirrhosis has been evaluated The usual dose of Hepcdac is 60mg as a single dose Hepcdac should be administered with or without food Recommended dosage regimens: Genotype I: Patients suffered by without cirrhosis: Hepcdac + Sofosbuvir for 12 weeks Compensated cirrhosis (child Pugh A): Hepcdac + Sofosbuvir for 12 weeks Decompensated cirrhosis (child Pugh B or C): Hepcdac + Sofosbuvir + ribavirin for 12 weeks Genotype III: Patients without cirrhosis: Hepcdac with Sofosbuvir for 12 weeks Compensated or decompensated cirrhosis: Hepcdac with Sofosbuvir + ribavirin for 12 weeks Dose adjustments: While concomitant with strong CYP3A inhibitors: 30mg of Hepcdac once a day Concomitant with moderate CYP3A inducers & nevirapine: 90mg of Hepcdac as single dose With strong CYP3A inducers: contraindicated Missed dose: Hepcdac is a prescription medicine; it should be used only under the guaindance of doctor Do not self medicate If patient fail to take the dose of Hepcdac tablet, must consult with physician and take the missed dose within the time Otherwise the missed dose should be skipped and follow the regular dosing schedule Do not take overdose

Side Effects of Hepcdac - 12 weeks

Pharmacological effects: CVS: Bradycardia, heart block, cardiac arrhythmias Liver: Increased AST & ALT, Hyperbilirubinaemia, hepatitis B reactivation Genitourinary: Urinary tract infection Ocular: Dry eye GIT: Abdominal pain, gastro esophageal reflux, vomiting, elevated lipase, flatulence Muscle: Myalgia, arthralgia, back pain Other: Fatigue, asthenia, influenza like symptoms, pyrexia, hot flush, loss of weight Nerve: Headache, migraine, somnolence Dermatological: Rashes, Pruritus, dry skin, alopecia, and Erythema multiforme Psychiatric: Insomnia, irritability, depression, anxiety Blood: Anemia, neutropenia, thrombocytopenia, esinophillia Respiratory: Cough, Nasopharyngitis, dyspnea, nasal congestion, upper respiratory infection Metabolic: Loss of appetite Some common side effects occurred in 12 weeks therapy; Chest pain, dizziness Irregular heart beat Unusual tiredness More common: Headache, nausea

Contraindication of Hepcdac - 12 weeks

Hepcdac with ribavirin contraindicated to pregnancy condition Hypersensitivity reaction occur Concurrent use of CYP3A inducers strong with Hepcdac, contraindicated to the patients

Drug Interaction of Hepcdac - 12 weeks

Concurrent use of Hepcdac with some drugs likes; Hepcdac is an inhibitor of P-glycoprotein transporter, organic anion transporting polypeptide and breast cancer resistance protein; taking Hepcdac, may elevate exposure to these drugs, which prolong the therapeutic effect Proteases inhibitors: increase effect of concentration of Hepcdac Efavirenz, etravirine & nevirapine: decrease the effect of concentration of Hepcdac Amiodarone: serious bradycardia occurs Aprepitant: increase the serum concentration of CYP3A4 substrates Strong inducers of CYP3A causes decreased therapeutic effect of Hepcdac Strong CYP3A inhibitors: increase the effect of concentration of Hepcdac HMG CoA reductase: increase the effect of concentration of these lipid lowering drugs

Precaution of Hepcdac - 12 weeks

There is a risk of adverse effects due to concurrent use of Hepcdac with some other drugs causes; Symptomatic bradycardia while using with amiodarone Risk related to ribavirin during combination Hepatitis B reactivation Loss of therapeutic effect Serious life threatening conditions

Usage & Safety profile of Hepcdac - 12 weeks Pregnancy & Lactation

During monotherapy: pregnancy category of Hepcdac -B; it is safe while using alone but under supervision of medical practitioner advice During combination: pregnancy categories Hepcdac with ribavirin-X; causes severe ill effects like fetal harm even to death Breast feeding is safe during monotherapy but in combination with ribavirin breast feeding is not recommended

Storage of Hepcdac - 12 weeks

Hepcdac tablets containers are stored at 25oC (77oF); excursion between 15oC and 30oC (59oF and 86oF) Keep away from heat, moisture and heat