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Hepcinat Plus


Availability: In stock

Special Price $ 625

BRAND : Hepcinat Plus
STRENGTH : 400mg & 60mg
INGREDIENT : Hepcinat-Plus-Natco-Sofosbuvir-400mg-Daclatasvir-60mg
COUNT : 28 Tablets

Description of Hepcinat Plus


Brand: Hepcinat plus
Active ingredients :Sofosbuvir & Daclatasvir
Company name: Natco Pharma Ltd
Packing: 28 tablets / bottle 
Strength: 400mg & 60mg

Pharmacology of Hepcinat Plus

Sofosbuvir expose to have a high barrier to the development of resistance and prevents the hepatitis C NS5B protein

Sofosbuvir interfere with the RNA polymerase enzyme by the integral worker which will implement the replication  process, Hence it blocks the reproduction of Hepatitis C virus and reduces the amount of Hepatitis  C virus in liver and thereby  Sofovir also acts to lessen liver  damage and reform liver function.

Daclatasvir is a direct acting antiviral drug which is used for the prevent hepatitis c virus infection.

Daclatasvir will focus the Hepatitis C virus and stops the numerous steps in replication process of HCV by the way it inhibits  the virus particles from making duplicate of themselves, and  helps the body to remove virus  from the blood.

Indication of Hepcinat Plus

Hepcinat plus is a combination of two antiviral drugs and manufactured by Natco.

Hepcinat plus is a fixed dose drug which is used along with or without ribavirin to treat the patients suffering from chronic hepatitis C virus genotype 1 or 3 infection.

Mechanism of action:

Sofosbuvir is a nucleotide correlated of the blockage of hepatitis C virus NS5B polymerase. The enzyme that interfere with  the proliferation of HCV RNA.  Sofosbuvir (GS-461203) which form triphosphate  act as the natural cellular uridine nucleotide and is fused by HCV RNA polymerase into the expansion of the RNA primer strand, which causes the completion of the viral chain.

Hepcinat plus which contains of Daclatasvir 60mg is a antiviral medication in which they also  interfere with nonstructural protein 5A (NS5A), a most functional protein which is an precise component of the Hepatitis C Virus reproduction complex. Daclatasvir block both viral RNA replication and virion complex.

Dose & Dosage's of Hepcinat Plus

Usual adult dose for patients with chronic hepatitis C virus has one tablet consist of Sofosbuvir 400mg and Daclatasvir 60mg.

Administered with or without food once daily taken orally.

Hepcinat plus administrated in patients with

Genotype 1: With compensated cirrhosis or without cirrhosis  needed 12 weeks therapy

Hepcinat plus and ribavirin combination is used for decompensated cirrhosis and posttransplant for 12 weeks.

Genotype 3: without cirrhosis needed for 12 weeks therapy. By ribavirin combination used for compensated or decompensated cirrhosis and posttransplant for 12 weeks.

OVERDOSAGE:   If overdose occur,. Seek medical emergency or call poison control for immediate treatment, since there is no unique antidote available for Hepcinat plus.

Side Effects of Hepcinat Plus

Adverse effects of Hepcinat plus

Common side effects:

  • Anemia
  • Loss Of Appetite
  • Depression
  • Anxiety
  • Insomnia
  • Dizziness
  • migraine
  • Athralgia, myalgia

Very common side effects:

Head pain, nausea, fatigue

Contraindication of Hepcinat Plus

When Hepcinat plus combine with ribavirin is contraindicated in pregnant women and avoid the drug during pregnancy.

Patient is contraindicated by having affected by hypersensitivity and renal hepatic  impairment.

Drug Interaction of Hepcinat Plus

When Hepcinat pus co administer with strong inhibitors of CYP3A4 that prevent P-gp activity and cause exposure of Hepcinat plus in limited effect

When Hepcinat pus co administer with strong inducers of CYP3A4 that lower exposure of Hepcinat plus and loss of efficacy.

Precaution of Hepcinat Plus

  • Hepcinat plus is a prescription drug, without prescription from doctor  should not be issued.
  • Combination of amiodarone may cause abnormally slow heart action.
  • If you are allergic to daclatasvir , Sofosbuvir or  have any other allergies before using the medicine. Both drug may consist  of inactive ingredients, that can  be cause allergic problems or other reaction. Discuss with your pharmacist for more details.
  • If you have any  renal disease, liver disease other than hepatitis C, tell to your consultant about past medical history before taking the daclatasvir / Sofosbuvir drug.

Usage & Safety profile of Hepcinat Plus Pregnancy & Lactation

Hepcinat plus belongs to category B has no sufficient and well developed studies in pregnant women and in animal reproduction studies also show no risk  and adverse effects to the fetus.

But when combination with ribavirin during pregnancy cause birth defect and even death to fetus. Hence  avoid these combination during pregnancy.

Lactation: Excretion into human milk is unknown and not recommended to mother to breast feed their infants during Hepcinat plus combination with ribavirin.

Storage of Hepcinat Plus

  • Store below 300C and Shelf life is 24 months
  • Keep it in cool, dry place and refrigeration is necessary,
  •  protect from light. Keep reach out of childerns
  • While travelling in car don’t keep it in glove box, drug can get too hot, cold or wet in box.
  • Container should be sealed and kept  its own original bottle. Don’t mix different drugs together.