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Xtandi

Xtandi Enzalutamide 40 mg

Availability: In stock

Special Price $ 7200

BRAND : Xtandi
STRENGTH : 40
INGREDIENT : Xtandi Enzalutamide 40 mg
COMPANY NAME : Medivation and Astellas Pharma
COUNT : 120 Tablets



Description of Xtandi

Xtandi is an Oncology medicine sophisticated in the treatment of advance prostate cancer in men. Important safety points of Xtandi 40mg : Do not use in female patient. Not recommended, if patient is pregnant, or may become pregnant. Not safe in children. Xtandi product information: Generic: Enzalutamide Trade name: Xtandi 40mg Mfg: Astella pharma Dosage form: Soft capsules Drug classification: Anti-cancer (Anti androgen)

Pharmacology of Xtandi

Mechanism of action involved in Tablet Xtandi: Xtandi is an androgen receptor inhibitor, which act in androgen receptor signaling pathway. It inhibits binding of androgen with androgen receptor. Inhibition of androgen receptor nuclear translocation occurs. It interacts with DNA. Pharmacological actions: Pharmacodynamic: Resistance to Xtandi has been identified. Up regulation of NF-52. Pharmacokinetics: Absorption : Xtandi is undergone first order absorption. Daily dosing 28 days Protein bound : Drug Xtandi, 97% to 98% of drug nearly bound to plasma proteins. Metabolism : Xtandi is a hepatically metabolized, and it converted into active metabolite. Elimination : Xtandi is eliminated by hepatic metabolism, it mainly excreted in urine. Half life: The half life period of Tablet Xtandi after a single dose is 5.8 days (approximately 7.8 to 8.6 days)

Indication of Xtandi

Primary indication of Xtandi medicine: Xtandi is mainly indicated for metastatic (advance) castration resistant prostate cancer, which has no longer responds in the medical or surgical therapy to lowers the testosterone levels.

Dose & Dosage's of Xtandi

Posology and administration of Tablet Xtandi-40: The prescribed dose of Xtandi is 160mg per day. It is available in the strength of 40mg. 4 tablets to be taken every day as a single dose. At the time of missed dose, patient should take it as close as possible otherwise skip the dose and follow the daily drug schedule in correct manner. Adjuvant use of strong CYP2C8 inhibitors with Xtandi: If patient takes strong CYP2C8 inhibitors with Xtandi, dose of the medicine Xtandi is decreased to 80mg once daily. Adjuvant use with strong CYP3A4 inducers with Drug Xtandi: If Xtandi used with CYP3A4 inducers, dose of the Drug Xtandi increased from 160mg to 240mg as a single use.

Side Effects of Xtandi

Xtandi can cause severe side effects including, Seizure Posterior Reversible Encephalopathy Syndrome (PRES) PRES is a high risk condition that occurred in the brain. Symptoms like, Headache,Decreased alertness, Confusion Dizziness,High blood pressure Other common side effects of Tablet Xtandi: Seizure, walking trouble, weakness of lower body, numbness, fever, cough, loss of bladder control, chest pain, shortness of breath, red or pink urine, anxiety, dizziness, insomnia, stuffy nose, sneezing, sore throat. Adverse reaction produced during the treatment of Drug Xtandi, General disorder : Asthenia condition Peripheral edema Muscle skeletal disorder: Back pain Arthralgia Muscle weakness, stiffness GIT disorder: Diarrhea Vascular disorder: Hot flush, hypertension Nerve system: Dizziness Spinal cord compression, paresthesia Mental impairment Hypoesthesia Infection & infestation: Upper and lower respiratory tract infection, Lung infection Mental disorder: Insomnia, anxiety Renal problems: Hematuria Pollakiuria Injury Fractures Skin reactions: Pruritus Dry skin Respiratory: Epistaxis

Contraindication of Xtandi

The drug Xtandi is highly contraindicated to pregnant women; it may leads to fetal death.

Drug Interaction of Xtandi

Drugs will affect the effect of Enzalutamide (Tablet Xtandi); Anti depressant Bronchodilators Birth control pills Hormone replacement Insulin Steroids Drug used to treat mental illness

Precaution of Xtandi

While taking Tablet Xtandi , patient may get serious health issues like Seizures and Posterior Reversible Encephalopathy Syndrome (PRES). In case of this condition, Xtandi should be discontinued and seek medical advice immediately. During sexual activity, birth control should be used for 3 months after the treatment. Important safety points of Xtandi 40 mg: Do not use in female patient. Not recommended, if patient is pregnant, or may become pregnant. Not safe in children. Before starting the treatment with drug Xtandi, medical history of the patient should know by medical practitioner; Patient already have seizures, brain injury, stroke, or brain tumors Patient should not take the drug Xtandi, in case of; Having prescription, or OTC (over the counter) drugs, vitamins and ayurvedic products. Mechanism of action involved in Tablet Xtandi: Xtandi is an androgen receptor inhibitor, which act in androgen receptor signaling pathway. It inhibits binding of androgen with androgen receptor. Inhibition of androgen receptor nuclear translocation occurs. It interacts with DNA. Primary indication of Xtandi medicine : is mainly indicated for metastatic (advance) castration resistant prostate cancer, which has no longer responds in the medical or surgical therapy to lowers the testosterone levels.

Usage & Safety profile of Xtandi Pregnancy & Lactation

Even though Tablet Xtandi is not recommended for women, it may come under pregnancy category X which represents fetal death.

Storage of Xtandi

Storage of Tablet Xtandi is between the ranges of 20oC-25oC (68oF-77oF) It is handling with care