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HepBest

HepatitisB-Mylan-Tenofovir-Alafenamide-25mg-HepBest

Availability: In stock

Special Price $ 80

BRAND : HepBest
STRENGTH : 25mg
INGREDIENT : HepatitisB-Mylan-Tenofovir-Alafenamide-25mg-HepBest
COMPANY NAME : Mylan
COUNT : 30 Tablets



Description of HepBest

Brand Name: HepBest
Ingredient: Tenofovir Alafenamide (TAF) 25mg
Manufacture: Mylan Pharmaceuticals Pvt. Ltd.
Packing: Pack of 30 tablets
category: anti-viral agent
HepBest tablet Description:
HepBest medicine prohibits the replication of HIV (human retro virus) and chronic hepatitis B (HBV) virus in human cells. Thus prevents the hepatitis B and HIV virus from generating new viruses.
 Mylan is the one of the most leading pharmaceutical company which acquired first approval and discriminated license from Gilead sciences for retailing HEPBEST in India.
 HEPBEST, an anti retroviral drug contains Tenofovir Alafenamide fumarate (TAF) as a active key ingredient.
 TAF is a nucleotide reverse transcriptase inhibitor (NRTI) which involves in the treatment of HIV infection and chronic hepatitis B infection.
 TAF is closely associated with reverse-transcriptase inhibitor Tenofovir disoproxil fumarate (TDF)
 Even if the TAF has a good drug safety profile and efficacy, it has some demerits like nephrotoxicity and which reduced bone mineral density.

Pharmacology of HepBest

HepBest Mechanism of Action:
HepBest contains an active ingredient Tenofovir Alafenamide Fumarate; it is a nucleotide reverse transcriptase inhibitor.
TAF is an ester prodrug of anti-retroviral, Tenofovir.
TAF is converted into tenofovir in vivo by using acyclic nucleoside phosphonate
Drug tenofovir decrease the normal DNA building blocks by lacking of OH molecules which is essential for phosphodiester bond linkage.
This linkage is responsible for DNA elongation
This leads to chain termination and prevents proviral DNA transcription.
Pharmacokinetics:
Absorption:
The absorption of tablet HepBest is normally high. Tmax is monitored at 1 hour after oral administration of tablet HepBest.
The volume of distribution is not available
Protein binding:
Tenofovir Alafenamide fumarate is highly bound to plasma protein; nearly 80% of drug is bounds to protein.
Metabolism:
TAF is hydrolyzed into Tenofovir which is occurs within the cells, it is a major metabolite.
Tenofovir is phosphorylated into active metabolite called tenofovir diphosphate.
Metabolism occurs by cathepsin A (Liposomal Protective Protein) in peripheral blood mononuclear cells and macrophages; and by Carboxyl esterase 1 (CES1) in hepatocytes.
Elimination:
The half life period of tablet HepBest is 0.51 hour.

Indication of HepBest

HepBest commonly used for the treatment of HIV infection and chronic hepatitis B infection (HBV).
HepBest involved in the treatment of chronic hepatitis (HCV) genotype I, II, III, IV, V &VI.

Dose & Dosage's of HepBest

HepBest is administered as single dose it is recommended for adolescent. The prescribed dose of HepBest tablet is 25mg.
HepBest should be taken with food.
Take one time each day

Side Effects of HepBest

 Diarrhea,
 Vomiting,
 Nausea,
 Dizziness,
 Rash,
 Feeling sick and more.
Serious side effects like;
Mental/mood chances: depression, anxiety, confusion
Signs of kidney problems
Unusual thirst
Liver and blood problems (lactic acidosis)
Abdominal pain
Yellowing eyes/skin
Dark urine
Drowsiness
Allergic reactions: rash, itching/swelling, dizziness, trouble breathing.
An adverse effect occurs during the therapy;
General:
Depression, asthenia, nausea, abdominal pain, insomnia, Pruritus, pyrexia
Gastrointestinal:
Pancreatitis, abdominal pain, elevated amylase, flatulence, dyspepsia, abdominal distension, elevated serum lipase
Metabolic:
Lactic acidosis, severe hepatomegaly with steatosis, hypokalemia, and hypophosphatemia, elevated fasting cholesterol, elevated triglycerides
With an anti retroviral treatment: accumulation of body fat occurs, lead to obesity
Dermatologic:
Pruritus, lipodystrophy, angioedema, Eosinophilia,
Psychiatric:
Insomnia, depression, anxiety, abnormal dreams
Nervous system:
Headache, dizziness, peripheral neuropathy, somnolence, paresthesia
Other:
Pyrexia, asthenia, fatigue, weight loss, chest pain, increased weight, procedural pain
Musculoskeletal:
Increased creatine kinase
Arthralgia, Myalgia, back pain, rhabdomyolysis, muscle weakness, myopathy, bone abnormalities, fractures, osteonecrosis, osteomalacia
Hepatic:
Elevated transaminase elevated ALT, AST, hepatic steatosis, elevated liver enzymes
Renal:
Increased creatinine, proximal renal tubulopathy (Fanconi syndrome), acute renal failure, acute tubular necrosis, nephrogenic diabetes insipidus, renal insufficiency, interstitial nephritis
Pulmonary:
Sinusitis, upper respiratory tract infection, Nasopharyngitis, pneumonia, pharyngolaryngeal pain, nasal congestion, dyspnea
Hematological:
Decreased neutrophils
Genitourinary:
Hematuria, glycosuria, decreased urine volume, Proteinuria, polyuria
Hypersensitivity:
Allergic reaction
Endocrine:
Increased serum parathyroid hormone levels
Immunological:
Grave’s disease, polymyositis, Guillain-Barre syndrome

Missed dose:
If patient fail to take a dose of Tablet HepBest means, it should be taken within the time.
Otherwise Patient should skip the dose and follow the regular drug dose schedule
Do not take two doses at the same time

Contraindication of HepBest

The following conditions are contraindicated;
Softening of bones, low amount of phosphate in blood, elevation in blood acidity due to high levels of lactic acid, fanconi’s syndrome, enlarged fatty liver, acute kidney failure, depletion of bone density, broken bone due to disease

Drug Interaction of HepBest

HepBest commonly used for the treatment of HIV infection and chronic hepatitis B infection (HBV). HepBest involved in the treatment of chronic hepatitis (HCV) genotype I, II, III, IV, V &VI.

Precaution of HepBest

If patient having lactic acidosis and severe hepatomegaly with steatosis, care should be taken while that patient treated with HepBest (TAF)
Lactic acidosis/severe hepatomegaly with steatosis
Severe acute exacerbation of Hepatitis B after discontinuation of treatment
Risk of development of HIV-1 resistance in patient’s co infected with HBV and HIV-1

Usage & Safety profile of HepBest Pregnancy & Lactation

In both conditions, tablet HepBest is safe to use; but prior information given to physician in case of pregnancy condition. There is a chance of placental transformation during labor Pediatric and geriatric usage not recommended.

Storage of HepBest

HepBest is stored under temperature at 30oC (86oF).