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Mechanism of Action
Hepbest (Tenofovir Alafenamide Fumarate (TAF)) is a Nucleotide Reverse Transcriptase Inhibitor (NRTI) and a novel ester prodrug of the antiretroviral,tenofovir. TAF is converted in vivo to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine monophosphate. Tenofovir mimics normal DNA building blocks but is lacking OH molecule required for phosphodiester bond linkage. By competing with regular nucleotides for incorporation into proviral DNA and prevention of the formation of phosphodiester linkage required for DNA elongation, tenofovir causes early chain termination and prevents proviral DNA transcription.
Coadministration of Hepbest with drugs that reduce renal function or compete for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs and this may increase the risk of adverse reactions.
Indications and Usage
Hepbest 25mg tablet is indicated for the treatment of chronic HBV infection in adults with compensated liver disease.
Administration and Dosage
The recommended dosage of HepBest 25mg tablets in for adults is once a day.
Take this medicine orally once daily with food.
Storage and Handling
Store below 30°C (86°F).
• Keep container tightly closed
• Dispense only in original container
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